Morishita Kiyofumi, Kurimoto Yoshihiko, Kawaharada Nobuyoshi, Fukada Johji, Hachiro Yoshikazu, Fujisawa Yasuaki, Abe Tomio
Department of Thoracic and Cardiovascular Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan.
Ann Thorac Surg. 2004 Nov;78(5):1630-4. doi: 10.1016/j.athoracsur.2004.05.014.
The mortality of patients with descending thoracic aortic rupture who are treated by conventional surgery is high. Our current strategy for the management of descending thoracic aortic rupture is to treat seriously ill patients with endovascular stent-grafting using handmade grafts, and to treat other patients with traditional open repair. The aim of this study was to assess the early results of our strategy.
Twenty-nine consecutive patients with descending thoracic aortic rupture were referred to Sapporo Medical University Hospital from June 2001 to January 2004. Eighteen of these 29 patients were selected for endovascular stent-grafting because of polytrauma (n = 7), comorbidities (n = 6), advanced age (n = 2), past history of left thoracotomy (n = 2), and patient's preference (n = 1). The remaining 11 patients underwent traditional graft replacement of the diseased aorta. Their outcomes and follow-up data were collected and analyzed retrospectively.
The in-hospital mortality rate was 14% (4/29). The mortality rate for surgical patients and stent-grafting patients was 9% (1/11) and 17% (3/18), respectively. The survival rate of patients at 2 years was 63% +/- 10%. In the follow-up period, 2 of the 18 patients who underwent endovascular stent-grafting required open repair, and 1 patient underwent a redo endovascular stent-grafting procedure because of stent failure. One of these 3 patients died of an intraoperative retrograde type A aortic dissection.
The early results of endovascular stent-grafting for the treatment of high-risk patients with descending thoracic aortic rupture are promising. Early results of open repair can also be improved by the selection of stabilized patients. However, the requirement of reintervention indicates that detailed follow-up examinations in patients who have undergone endovascular stent-grafting with handmade stent-grafts should be performed.
接受传统手术治疗的降主动脉破裂患者死亡率较高。我们目前治疗降主动脉破裂的策略是,对于病情严重的患者采用手工制作的移植物进行血管内支架植入治疗,对于其他患者则采用传统的开放修复手术。本研究的目的是评估我们这一策略的早期效果。
2001年6月至2004年1月期间,29例连续性降主动脉破裂患者被转诊至札幌医科大学医院。这29例患者中,18例因多发伤(7例)、合并症(6例)、高龄(2例)、既往左胸手术史(2例)及患者意愿(1例)而被选择进行血管内支架植入治疗。其余11例患者接受了病变主动脉的传统移植物置换术。对他们的结局和随访数据进行回顾性收集和分析。
住院死亡率为14%(4/29)。手术患者和支架植入患者的死亡率分别为9%(1/11)和17%(3/18)。患者2年生存率为63%±10%。在随访期间,18例行血管内支架植入治疗的患者中有2例需要进行开放修复,1例患者因支架故障而接受再次血管内支架植入手术。这3例患者中有1例死于术中逆行性A型主动脉夹层。
血管内支架植入治疗降主动脉破裂高危患者的早期效果令人鼓舞。通过选择病情稳定的患者,开放修复的早期效果也可得到改善。然而,再次干预的需求表明,对于接受手工制作支架的血管内支架植入治疗的患者,应进行详细的随访检查。