T细胞介导的药物超敏反应的细胞机制。

Cellular mechanisms of T cell mediated drug hypersensitivity.

作者信息

Gerber Basil O, Pichler Werner J

机构信息

Division of Allergology, Clinic for Rheumatology and Clinical Immunology/Allergology, PKT2 D572, Inselspital, CH-3010 Berne, Switzerland.

出版信息

Curr Opin Immunol. 2004 Dec;16(6):732-7. doi: 10.1016/j.coi.2004.09.016.

DOI:10.1016/j.coi.2004.09.016

PMID:15511665

Abstract

Noncovalent drug presentation leads to the activation of drug-specific T cells. In some patients with hypersensitivity, such a response occurs within hours even upon the first exposure to the drug. Thus, the reaction to the drug might not be due to a classical, primary response, but rather mediated by existing, preactivated T cells that are cross specific for the drug, and have an additional (peptide) specificity as well.

摘要

非共价药物呈递可导致药物特异性T细胞的激活。在一些过敏患者中，即使首次接触药物，这种反应也会在数小时内发生。因此，对药物的反应可能不是由于经典的初次反应，而是由对该药物具有交叉特异性且还具有额外（肽）特异性的现有预激活T细胞介导的。