Pichler Werner J
Department for Rheumatology and Clinical Immunology/Allergology, Inselspital, University of Bern, Bern, Switzerland.
ALTEX. 2007;24 Spec No:49-52.
Recently it was found that drugs causing drug hypersensitivities do not only rely on the formation of hapten-carrier conjugates but can stimulate T cells directly via their T cell receptors for antigen. This new mechanism was termed pharmacological interaction of drugs with immune receptors (p-i concept). It is frequent in systemic drug hypersensitivity reactions and has major implications for predicting them. First experiments to identify such drugs able to interact with T cells are presented.
最近发现，引起药物超敏反应的药物不仅依赖于半抗原-载体缀合物的形成，还可通过其抗原T细胞受体直接刺激T细胞。这种新机制被称为药物与免疫受体的药理学相互作用（p-i概念）。它在全身性药物超敏反应中很常见，对预测此类反应具有重要意义。本文展示了识别此类能够与T细胞相互作用的药物的初步实验。
