SLE 的明星靶点：IL-17。
The star target in SLE: IL-17.
机构信息
Department of Rheumatology and Immunology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
出版信息
Inflamm Res. 2023 Feb;72(2):313-328. doi: 10.1007/s00011-022-01674-z. Epub 2022 Dec 20.
PURPOSE
The purpose of this review is to discuss the significance of IL-17 in SLE and the potential of IL-17-targeted therapy.
BACKGROUND
Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect many organs and tissues throughout the body. It is characterized by overactive B and T cells and loss of immune tolerance to autoantigens. Interleukin-17 (IL-17) is a cytokine that promotes inflammation and has been implicated in the pathogenesis of several autoimmune diseases as well as inflammatory diseases. In in vitro cellular experiments in lupus susceptible mice or SLE patients, there is substantial evidence that IL-17 is a highly promising therapeutic target.
METHODS
We searched papers from PubMed database using the search terms, such as interleukin-17, systemic lupus erythematosus, treatment targets, T cells, lupus nephritis, and other relevant terms.
RESULTS
We discuss in this paper the molecular mechanisms of IL-17 expression, Th17 cell proliferation, and the relationship between IL-17 and Th17. The significance of IL-17 in SLE and the potential of IL-17-targeted therapy are further discussed in detail.
CONCLUSION
IL-17 has a very high potential for the development as a star target in SLE.
目的
本文旨在讨论白细胞介素 17（IL-17）在系统性红斑狼疮（SLE）中的意义以及针对 IL-17 的治疗潜力。
背景
系统性红斑狼疮（SLE）是一种自身免疫性疾病，可影响全身多个器官和组织。其特征是 B 细胞和 T 细胞过度活跃，以及对自身抗原的免疫耐受丧失。白细胞介素 17（IL-17）是一种促炎细胞因子，与多种自身免疫性疾病和炎症性疾病的发病机制有关。在狼疮易感小鼠或 SLE 患者的体外细胞实验中，有大量证据表明 IL-17 是一个极具前景的治疗靶点。
方法
我们使用了“interleukin-17”、“systemic lupus erythematosus”、“treatment targets”、“T cells”、“lupus nephritis”等关键词，在 PubMed 数据库中检索了相关文献。
结果
本文讨论了 IL-17 表达、Th17 细胞增殖的分子机制，以及 IL-17 与 Th17 的关系。此外，还详细探讨了 IL-17 在 SLE 中的意义以及 IL-17 靶向治疗的潜力。
结论
IL-17 作为 SLE 的明星靶点具有很大的发展潜力。
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