Kaufman L D
Division of Allergy, Rheumatology, and Clinical Immunology, State University of New York, Stony Brook 11794-8161.
Clin Exp Rheumatol. 1992 Jan-Feb;10(1):87-91.
The eosinophilia-myalgia syndrome (EMS) is a recently described systemic disorder distinguished by the development of characteristic muscle spasm, myalgia, neuropathy, and scleroderma-like cutaneous induration. Life-threatening manifestations have included cardiopulmonary and acute ascending neuropathic syndromes. Current evidence indicates that this is a severe illness with the potential for long-term disability. Careful follow-up studies will help to better define new features of this disease, such as the recent awareness of severe neurocognitive abnormalities in some patients. The association of EMS with the ingestion of L-tryptophan may provide important clues toward the understanding of idiopathic fibrosing syndromes, as well as toxin-induced autoimmune phenomena. Rational therapy will be dependent upon a more complete understanding of the pathogenesis of this and related diseases.
嗜酸性粒细胞增多性肌痛综合征（EMS）是一种最近才被描述的全身性疾病，其特征为出现典型的肌肉痉挛、肌痛、神经病变以及硬皮病样皮肤硬结。危及生命的表现包括心肺综合征和急性上行性神经病变综合征。目前的证据表明，这是一种严重疾病，有可能导致长期残疾。仔细的随访研究将有助于更好地明确该疾病的新特征，比如最近发现的一些患者存在严重神经认知异常。EMS与摄入L-色氨酸之间的关联可能为理解特发性纤维化综合征以及毒素诱导的自身免疫现象提供重要线索。合理的治疗将依赖于对该疾病及相关疾病发病机制更全面的了解。
