Chiò Adriano, Herrero Hernandez Elena, Mora Gabriele, Valentini Consuelo, Discalzi Gianluigi, Pira Enrico
Neuroscience, University of Turin, Italy.
Amyotroph Lateral Scler Other Motor Neuron Disord. 2004 Sep;5(3):188-91. doi: 10.1080/14660820410018414.
A 34-years-old floor-layer developed optic neuropathy and motor neuron disease after being accidentally exposed to a solvent mixture containing methanol and other substances. Optic neuropathy is a complication of methanol poisoning, but the onset of a motor neuron disorder resembling amyotrophic lateral sclerosis after the exposure to these substances has not been previously described. The temporal onset of the clinical symptoms, biological plausibility, young age of the patient and absence of neurological disorders in the family history raises suspicion of a possible causative relationship.
一名34岁的地板铺设工人在意外接触含有甲醇和其他物质的溶剂混合物后，患上了视神经病变和运动神经元疾病。视神经病变是甲醇中毒的一种并发症，但此前尚未有过在接触这些物质后出现类似肌萎缩侧索硬化的运动神经元疾病发作的描述。临床症状的发作时间、生物学合理性、患者的年轻年龄以及家族史中无神经系统疾病，引发了对可能因果关系的怀疑。
