Gold James M, Poet Michael S, Wilk Christopher M, Buchanan Robert W
Maryland Psychiatric Research Center, PO Box 21247, Baltimore, MD 21228, USA.
J Clin Exp Neuropsychol. 2004 Jun;26(4):511-20. doi: 10.1080/13803390490496669.
We investigated the use of the Family Pictures test from the Wechsler Memory Scale III as a measure of the ability to bind the multiple features of a complex visual scene in a study group of 77 patients with schizophrenia and 44 healthy controls. Patients demonstrated impaired recall of all scene features as well as a reduction in the number of features recalled for each remembered character. Secondary analyses using patients and controls matched for character recall also showed reduced feature binding in the patient group. Such feature binding deficits likely implicate hippocampal dysfunction, consistent with neuroimaging evidence of structural and functional compromise of the medial temporal lobe in schizophrenia.
我们在一个由77名精神分裂症患者和44名健康对照者组成的研究组中，研究了韦氏记忆量表第三版中的家庭图片测试，以此作为衡量整合复杂视觉场景多个特征能力的一种方法。患者在回忆所有场景特征方面表现受损，并且每个被记住人物所回忆出的特征数量也有所减少。使用在人物回忆方面相匹配的患者和对照者进行的二次分析也显示，患者组的特征整合能力下降。这种特征整合缺陷可能暗示海马体功能障碍，这与精神分裂症患者内侧颞叶结构和功能受损的神经影像学证据相一致。
