Bakermans-Kranenburg M J, Van Ijzendoorn M H
Attach Hum Dev. 2004 Sep;6(3):211-8; discussion 219-22. doi: 10.1080/14616730412331281584.
In a first molecular genetic study Lakatos and colleagues found an association between attachment disorganization and the dopamine D4 receptor (DRD4) gene polymorphism, in particular in the presence of the -521 T allele in the promoter region of the DRD4 gene. Replication of their study in a sample of 132 infants did not confirm the role of the DRD4 7+ -allele and the -521C/T promoter gene in disorganized attachment. Although our sample was larger, and contained more children with CT or TT alleles, which enhanced the probability of finding the DRD4 and C/T interaction, the association was not found. Even when we combined our sample with the Lakatos sample, the interaction effect of the DRD4 and -521 C/T polymorphisms on disorganized attachment was absent.
在第一项分子遗传学研究中，拉卡托斯及其同事发现依恋紊乱与多巴胺D4受体（DRD4）基因多态性之间存在关联，特别是在DRD4基因启动子区域存在-521 T等位基因的情况下。他们在132名婴儿样本中重复该研究，未证实DRD4 7+等位基因和-521C/T启动子基因在紊乱依恋中的作用。尽管我们的样本更大，且包含更多携带CT或TT等位基因的儿童，这增加了发现DRD4与C/T相互作用的可能性，但未发现这种关联。即使我们将我们的样本与拉卡托斯的样本合并，DRD4和-521 C/T多态性对紊乱依恋的相互作用效应也不存在。
