Schlegel Ulf J, Sturm Michael, Ewerbeck Volker, Breusch Steffen J
Department of Orthopaedics, University of Heidelberg, Germany.
Acta Orthop Scand. 2004 Oct;75(5):559-66. doi: 10.1080/00016470410001420.
Polymethylmethacrylate (PMMA) bone cements are mainly used for implant fixation in joint replacement surgery. During cement preparation for application, all staff in the operating theatre are exposed to methylmethacrylate (MMA) fumes, which are known to have toxic side effects.
In this study we found that vacuum mixing of bone cement with 7 commercially available mixing devices significantly reduced the emission of MMA vapors in the breathing zone when compared with classic hand mixing in an open bowl. Gas chromatography appears to be more sensitive for detection of MMA fumes than Photo Inonization Detection.
According to present knowledge, even repeated mixing of PMMA bone cement during a normal working day does not seem to constitute an increased health risk, particularly if vacuum mixing is implemented.
聚甲基丙烯酸甲酯（PMMA）骨水泥主要用于关节置换手术中的植入物固定。在准备使用骨水泥的过程中，手术室的所有工作人员都会接触到甲基丙烯酸甲酯（MMA）烟雾，已知其具有毒副作用。
在本研究中，我们发现，与在敞口碗中进行传统手工搅拌相比，使用7种市售搅拌设备对骨水泥进行真空搅拌可显著减少呼吸区域内MMA蒸汽的排放。气相色谱法在检测MMA烟雾方面似乎比光离子化检测更为灵敏。
根据目前的认识，即使在正常工作日对PMMA骨水泥进行反复搅拌，似乎也不会增加健康风险，尤其是在采用真空搅拌的情况下。
