Brizard Christian P, Olsson Christian, Wilkinson James L
Cardiac Surgery Unit and Department of Cardiology, Royal Children's Hospital, Parkville 3052, Victoria, Australia.
J Thorac Cardiovasc Surg. 2004 Nov;128(5):684-92. doi: 10.1016/j.jtcvs.2004.05.018.
This was an evaluation of a new approach to the management of multiple muscular ventricular septal defects. The defects were located with epicardial echocardiography, then transfixed with a guide wire inserted directly through the right ventricular free wall. They were closed with a custom-made multilayered double-patch device under cardioplegic arrest through a standard right atriotomy.
This was a retrospective study of 14 consecutive patients.
The median age and body weight at repair were 40 days (range 1 week-8 years, 3 months) and 4.1 kg (2.8-24 kg), respectively. Five patients (36%) had undergone at least one previous sternotomy; 11 patients (78%) had associated cardiac lesions. Closure of the multiple septal defects was successful in 12 patients (85%). Failure to localize all defects led to pulmonary artery banding in 2 patients. One patient had the residual septal defect closed with a percutaneous device 6 months later, and in the second patient the residual defect was closed with a conventional approach 11 months afterward. Two patients had permanent pacemaker insertion. In 279 patient-months of follow-up, there was 1 cardiac arrest on day 1 and no early or late deaths; all children but one are free of cardiac medications, and no significant residual left-to-right shunts were demonstrated in any patient.
The reported management of multiple ventricular septal defects has been successful in this series, even in neonates and infants with complex associated cardiac lesions. It appears safe, simple, and effective.
本研究旨在评估一种治疗多发性肌部室间隔缺损的新方法。通过心外膜超声心动图定位缺损,然后直接经右心室游离壁插入导丝进行穿刺。在心脏停搏状态下,经标准右心房切口,使用定制的多层双补片装置封闭缺损。
这是一项对14例连续患者的回顾性研究。
修复时的中位年龄和体重分别为40天(范围1周 - 8岁3个月)和4.1千克(2.8 - 24千克)。5例患者(36%)此前至少接受过一次胸骨切开术;11例患者(78%)合并有心脏病变。12例患者(85%)成功封闭了多个室间隔缺损。2例患者因未能定位所有缺损而进行了肺动脉环扎术。1例患者在6个月后经皮装置封闭了残余室间隔缺损,另1例患者在11个月后采用传统方法封闭了残余缺损。2例患者植入了永久性起搏器。在279个患者 - 月的随访中,术后第1天发生1次心脏骤停,无早期或晚期死亡;除1例外,所有患儿均无需服用心脏药物,且所有患者均未发现明显的残余左向右分流。
本系列报道的多发性室间隔缺损治疗方法取得了成功,即使是合并复杂心脏病变的新生儿和婴儿。该方法似乎安全、简单且有效。