长期接受抗癫痫治疗患者溶血产物中的血红蛋白谷胱甘肽加合物（Hb ASSG）
Glutathione adduct of hemoglobin (Hb ASSG) in hemolysates of patients on long-term antiepileptic therapy.
作者信息
Niketić V, Beslo D, Raicević S, Sredić S, Stojković M
机构信息
Department of Chemistry, Faculty of Science, University of Belgrade, Yugoslavia.
出版信息
Int J Biochem. 1992 Mar;24(3):503-7. doi: 10.1016/0020-711x(92)90046-4.
PMID:1551464
Abstract
- A novel, hitherto unrecognized, hemoglobin fraction, HbA1x, has been detected in amounts up to 7% of the total Hb, in hemolysates from epileptic patients with long-term therapy containing phenobarbital (PB) and carbamazepine (Carb). 2. HbA1x was shown to represent glutathione adduct of Hb (Hb ASSG). 3. To our knowledge, this is the first demonstration of the occurrence of Hb ASSG in vivo.
摘要
- 在长期接受苯巴比妥（PB）和卡马西平（Carb）治疗的癫痫患者的溶血产物中，检测到一种新的、迄今未被认识的血红蛋白组分HbA1x，其含量高达总血红蛋白的7%。2. 已证明HbA1x代表血红蛋白的谷胱甘肽加合物（Hb ASSG）。3. 据我们所知，这是首次在体内证明Hb ASSG的存在。
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Glutathione adduct of hemoglobin (Hb ASSG) in hemolysates of patients on long-term antiepileptic therapy.长期接受抗癫痫治疗患者溶血产物中的血红蛋白谷胱甘肽加合物（Hb ASSG）
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