Suprun I V, Mel'nichenko A A, Yanushevskaya E V, Vlasik T N, Sobenin I A, Panasenko O M, Orekhov A N
Laboratory for Mechanisms of Atherogenesis, Institute of Experimental Cardiology, Russian Research-and-Production Complex for Cardiology, Russian Ministry of Health, Moscow.
Bull Exp Biol Med. 2004 Jul;138(1):42-4. doi: 10.1023/b:bebm.0000046934.76907.9d.
The state of apo-B in native and circulating modified low-density lipoproteins was studied by solid-phase enzyme immunoassay. We studied the interaction of these particles with monoclonal antibodies to apo-B of low-density lipoproteins. Native and circulating modified low-density lipoproteins had different affinity for the studied antigens. Our results illustrate conformational changes in apo-B of circulating modified low-density lipoproteins compared to native low-density lipoproteins. These changes probably contribute to increased accumulation of particles in vascular cells and their transformation into foam cells giving way to atherosclerotic vascular lesions.
