Site-specific oxidative cleavage of DNA by metallosalen-DNA conjugates.
作者信息
Czlapinski Jennifer L, Sheppard Terry L
机构信息
Northwestern University, Department of Chemistry, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.
出版信息
Chem Commun (Camb). 2004 Nov 7(21):2468-9. doi: 10.1039/b410493e. Epub 2004 Sep 24.
DOI:10.1039/b410493e
PMID:15514819
Abstract
Ni-salen-DNA conjugates, prepared by template-directed synthesis, targeted oxidative adduct formation and strand scission at deoxyguanosine sites in complementary DNA strands of Watson-Crick duplexes.
摘要
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