[涎腺腺样囊性癌中p53基因突变的分析。]
[Analysis of p53 gene mutation in salivary adenoid cystic carcinoma.].
作者信息
Zhang Dong-sheng, Bian Cui-rong, Wang Pei-yu, Yuan Xi-lan, Wang Jia-yao
机构信息
Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital, Shandong University, Jinan 250021, Shandong Province, China.
出版信息
Shanghai Kou Qiang Yi Xue. 2004 Oct;13(5):396-8.
PURPOSE
The purpose of this study was to investigate the occurrence of p53 gene mutation in salivary adenoid cystic carcinoma, the correlation between the gene and prognostic significance.
METHODS
A series of salivary adenoid cystic carcinoma were studied by polymerase chain reaction and single strand conformation polymorphism (PCR-SSCP) analysis to detect p53 mutation, respectively.
RESULTS
The result showed that p53 gene mutations in exon 5-8 were detected in 65.8% (25/38) of the salivary adenoid cystic carcinoma. The p53 gene mutation was related to tumor distant metastasis and tumor recurrence (P<0.05) but not related to pathological types, clinical stages (P>0.05).There was a significant correlation between p53 gene mutation and postoperative survival .
CONCLUSION
It is suggested that p53 gene mutations were very common in salivary adenoid cystic carcinoma, and might be useful in screening progress and evaluating prognosis of patients.
目的
本研究旨在探讨唾液腺腺样囊性癌中p53基因突变的发生情况、该基因与预后的相关性及意义。
方法
采用聚合酶链反应和单链构象多态性分析（PCR-SSCP）对一系列唾液腺腺样囊性癌进行研究，以检测p53基因突变。
结果
结果显示，65.8%（25/38）的唾液腺腺样囊性癌检测到外显子5-8的p53基因突变。p53基因突变与肿瘤远处转移和肿瘤复发相关（P<0.05），但与病理类型、临床分期无关（P>0.05）。p53基因突变与术后生存率之间存在显著相关性。
结论
提示p53基因突变在唾液腺腺样囊性癌中非常常见，可能有助于筛选患者病情进展及评估预后。
Zotero 插件