Brecht Michael, Krauss Andreas, Muhammad Sajjad, Sinai-Esfahani Laleh, Bellanca Sebastiano, Margrie Troy W
Department of Cell Physiology, Max-Planck Institute for Medical Research, D-69120 Heidelberg, Germany.
J Comp Neurol. 2004 Nov 22;479(4):360-73. doi: 10.1002/cne.20306.
The relationship between motor maps and cytoarchitectonic subdivisions in rat frontal cortex is not well understood. We use cytoarchitectonic analysis of microstimulation sites and intracellular stimulation of identified cells to develop a cell-based partitioning scheme of rat vibrissa motor cortex and adjacent areas. The results suggest that rat primary motor cortex (M1) is composed of three cytoarchitectonic areas, the agranular medial field (AGm), the agranular lateral field (AG1), and the cingulate area 1 (Cg1), each of which represents movements of different body parts. Vibrissa motor cortex corresponds entirely and for the most part exclusively to AGm. In area AG1 body/head movements can be evoked. In posterior area Cg1 periocular/eye movements and in anterior area Cg1 nose movements can be evoked. In all of these areas stimulation thresholds are very low, and together they form a complete representation of the rat's body surface. A strong myelinization and an expanded layer 5 characterize area AGm. We suggest that both the strong myelinization and the expanded layer 5 of area AGm may represent cytoarchitectonic specializations related to control of high-speed whisking behavior.
大鼠额叶皮质中运动图谱与细胞构筑亚区之间的关系尚未完全明确。我们通过对微刺激位点进行细胞构筑分析以及对已识别细胞进行细胞内刺激，来制定大鼠触须运动皮质及相邻区域基于细胞的分区方案。结果表明，大鼠初级运动皮质（M1）由三个细胞构筑区域组成，即无颗粒内侧区（AGm）、无颗粒外侧区（AG1）和扣带区1（Cg1），每个区域代表不同身体部位的运动。触须运动皮质完全对应且大部分仅对应于AGm。在AG1区可诱发身体/头部运动。在Cg1区后部可诱发眼周/眼部运动，在Cg1区前部可诱发鼻部运动。在所有这些区域，刺激阈值都非常低，它们共同构成了大鼠体表的完整表征。AGm区有强烈的髓鞘形成和扩展的第5层。我们认为，AGm区强烈的髓鞘形成和扩展的第5层可能代表与高速摆动触须行为控制相关的细胞构筑特化。
