Chen Xi, Ji Tianhai, Yao Liqing, Yang Jingsong, Deng Jun, Zhang Zaigen
Department of Otolaryngology, Affiliated First Hospital, Fujian Medical University, Fuzhou 350005.
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2002 Sep;16(9):459-61.
To study the correlation of expression implication of MDR genes (GST-pi and Topo II) and MDR gene-coded product (Pgp) with prognosis in laryngopharyngeal malignant melanoma.
Using immunohistochemical S-P method,expression of GST-pi, Topo II and Pgp was detected in 28 cases of laryngopharyngeal malignant melanoma. The relationship between GST-pi, Topo II, Pgp and clinicopathological features, prognosis of the tumors were also analyzed.
The positive rates of Pgp, GST-pi and Topo II were 35.7%, 57.1% and 46.4% respectively in 28 cases of laryngopharyngeal malignant melanoma, without significant difference (P > 0.05). The positive rates of Pgp, GST-pi and Topo II were not correlated with sex,age, size of tumor and Clark's grade, Breslow's grade (P > 0.05), but AJC grade and prognosis (P < 0.05).
Expression of Pgp,GST-pi and Topo II may be the chief mechanism of multi-drug resistance. Detection of multi-drug resistance genes is of necessity and feasibility when predicting the effect of chemotherapy.
