Blais L, Beauchesne M-F
Faculty of Pharmacy, Université de Montréal and Hôpital du Sacré-Coeur de Montréal, Québec, Canada.
Thorax. 2004 Nov;59(11):943-7. doi: 10.1136/thx.2004.022475.
Most patients who have an asthma exacerbation leading to a visit to an emergency department (ED) will benefit from treatment with inhaled corticosteroids (ICS) at discharge. We investigated whether asthmatic children and adolescents were receiving ICS after discharge from the ED and identified the characteristics of patients and physicians associated with their use.
A cohort of 4042 asthmatic patients aged 5-17 years was selected from the administrative database of the Regie de l'assurance maladie du Quebec between 1997 and 1999. The proportion of patients using ICS 1, 3, and 6 months after ED discharge was estimated. Using GEE models the independent contribution of sociodemographic variables, markers of asthma severity, prior use of healthcare services and ICS, and physician characteristics was investigated on the likelihood of using ICS after ED discharge.
68% of children and 51% of adolescents had a valid prescription for ICS in the month following discharge. At 6 months after discharge the corresponding figures were 77% and 60%. The strongest predictors of ICS use were age, with adolescents being less likely to use ICS than children (OR 0.49; 95% CI 0.43 to 0.56), prior use of ICS (OR 2.28; 95% CI 2.00 to 2.61), and filling a prescription for oral corticosteroids in the month following discharge (OR 2.29; 95% CI 2.03 to 2.58). However, patients who had an ED visit or a hospital admission for asthma during the 6 months before discharge were not more likely to use ICS after discharge.
A large proportion of patients with clear markers of uncontrolled or severe asthma did not have a valid prescription for an ICS after discharge from the ED.
大多数因哮喘急性加重而前往急诊科就诊的患者在出院时接受吸入性糖皮质激素(ICS)治疗会受益。我们调查了哮喘儿童和青少年在急诊科出院后是否接受ICS治疗,并确定了与使用ICS相关的患者和医生特征。
从魁北克医疗保险管理数据库中选取了1997年至1999年间4042名5至17岁的哮喘患者队列。估计了患者在急诊科出院后1个月、3个月和6个月使用ICS的比例。使用广义估计方程(GEE)模型研究了社会人口统计学变量、哮喘严重程度标志物、先前医疗服务和ICS的使用情况以及医生特征对急诊科出院后使用ICS可能性的独立影响。
68%的儿童和51%的青少年在出院后1个月有有效的ICS处方。出院后6个月时,相应数字分别为77%和60%。使用ICS的最强预测因素是年龄,青少年使用ICS的可能性低于儿童(比值比[OR]0.49;95%置信区间[CI]0.43至0.56)、先前使用ICS(OR 2.28;95%CI 2.00至2.61)以及在出院后1个月开具口服糖皮质激素处方(OR 2.29;95%CI 2.03至2.58)。然而,在出院前6个月内因哮喘就诊或住院的患者出院后使用ICS的可能性并未增加。
很大一部分有明确未控制或严重哮喘标志物的患者在急诊科出院后没有有效的ICS处方。