To Teresa, Wang Chengning, Dell Sharon, Fleming-Carroll Bonnie, Parkin Patricia, Scolnik Dennis, Ungar Wendy
Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
Ambul Pediatr. 2008 Sep-Oct;8(5):281-7. doi: 10.1016/j.ambp.2008.04.008. Epub 2008 Jun 27.
The aim of this study was to identify risk factors for long-term adverse outcomes in children with asthma after visiting the emergency department (ED).
A prospective observational study was conducted at the ED of a pediatric tertiary hospital in Ontario, Canada. Patient outcomes (ie, acute asthma episodes and ED visits) were measured at baseline and at 1- and 6-months post-ED discharge. Time trends in outcomes were assessed using the generalized estimating equations method. Multiple conditional logistic regressions were used to model outcomes at 6 months and examine the impact of drug insurance coverage while adjusting for confounders.
Of the 269 children recruited, 81.8% completed both follow-ups. ED use significantly reduced from 39.4% at baseline to 26.8% at 6 months (P < .001), whereas the level of acute asthma episodes remained unchanged. Children with drug insurance coverage were less likely to have acute asthma episodes (adjusted odds ratio [AOR] = 0.36; 95% CI, 0.15-0.85; P < .02) or repeat ED visits (AOR = 0.45; 95% CI, 0.20-0.99; P < .05) at 6 months. Other risk factors for adverse outcomes included previous adverse asthma events and certain asthma triggers (eg, cold/sinus infection). Washing bed linens in hot water weekly was protective against subsequent acute asthma episodes.
Our study demonstrated significant improvements in long-term outcomes in children seeking acute care for asthma in the ED. Future efforts remain in targeting the sustainability of improved outcomes beyond 6 months. Risk factors identified can help target vulnerable populations for proper interventions, which may include efforts to maximize insurance coverage for asthma medications and strategies to improve asthma self-management through patient and provider education.
本研究旨在确定哮喘患儿在急诊科就诊后长期不良结局的风险因素。
在加拿大安大略省一家儿科三级医院的急诊科进行了一项前瞻性观察研究。在基线以及急诊科出院后1个月和6个月时测量患者结局(即急性哮喘发作和急诊科就诊情况)。使用广义估计方程法评估结局的时间趋势。采用多条件逻辑回归对6个月时的结局进行建模,并在调整混杂因素的同时检验药物保险覆盖范围的影响。
在招募的269名儿童中,81.8%完成了两次随访。急诊科就诊率从基线时的39.4%显著降至6个月时的26.8%(P <.001),而急性哮喘发作水平保持不变。有药物保险覆盖的儿童在6个月时发生急性哮喘发作(调整后的优势比[AOR]=0.36;95%可信区间,0.15 - 0.85;P <.02)或再次急诊科就诊(AOR = 0.45;95%可信区间,0.20 - 0.99;P <.05)的可能性较小。不良结局的其他风险因素包括既往不良哮喘事件和某些哮喘触发因素(如感冒/鼻窦感染)。每周用热水清洗床单可预防随后的急性哮喘发作。
我们的研究表明,在急诊科寻求急性哮喘治疗的儿童长期结局有显著改善。未来仍需努力实现6个月后改善结局的可持续性。确定的风险因素有助于针对弱势群体进行适当干预,这可能包括努力使哮喘药物的保险覆盖最大化,以及通过患者和提供者教育来改善哮喘自我管理的策略。