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关节内注射皮质类固醇:缓解髋关节骨关节炎疼痛?

Intraarticular corticosteroid injection: pain relief in osteoarthritis of the hip?

作者信息

Kullenberg Björn, Runesson Ronny, Tuvhag Richard, Olsson Christer, Resch Sylvia

机构信息

Department of Orthopedics, Blekinge Hospital, Karlshamn, Sweden.

出版信息

J Rheumatol. 2004 Nov;31(11):2265-8.

Abstract

OBJECTIVE

Osteoarthritis (OA) is one of the most common causes of morbidity in the elderly population, and surgery is often preceded by years of pain and disability. Intraarticular corticosteroid injections in osteoarthritic joints may play a role in the therapeutic plan and can afford quick pain relief but do not alter the underlying disease. There is a paucity of well controlled studies that provide recommendations for the use of corticosteroids in OA of the hip.

METHODS

A prospective analysis of 80 patients with OA of the hip and pain at rest and on bearing weight for more than 4 weeks was performed. Patients were randomized into 2 groups; group 1 (n = 40) received corticosteroid (80 mg triamcinolone acetonide) and group 2 (n = 40) local anesthetic (1% mepivacaine), injected into the hip joint under fluoroscopy. Pain, functional ability, range of motion of the joint, and analgesics consumed were registered 3 weeks postinjection. The treatment was blind for the patients and the investigators performing the followup.

RESULTS

Pain for all modalities decreased after corticosteroid injection, but pain at rest decreased the most. There was significant pain reduction at the 3 (and 12) week followup. Joint range of motion increased significantly for all directions. Functional ability improved significantly after injection. We found no significant pain relief or improvement of functional ability in patients treated with local anesthetics.

CONCLUSION

This study suggests that intraarticular corticosteroids might improve pain and range of motion of the affected joint in patients with hip OA.

摘要

目的

骨关节炎(OA)是老年人群发病的最常见原因之一,手术前往往有多年的疼痛和功能障碍。在骨关节炎关节内注射皮质类固醇可能在治疗方案中发挥作用,能迅速缓解疼痛,但不会改变潜在疾病。目前缺乏对皮质类固醇在髋部骨关节炎中应用的充分对照研究并提供相关建议。

方法

对80例髋部骨关节炎且静息和负重时疼痛超过4周的患者进行前瞻性分析。患者被随机分为两组;第1组(n = 40)接受皮质类固醇(80mg曲安奈德),第2组(n = 40)接受局部麻醉剂(1%甲哌卡因),在荧光透视下注入髋关节。在注射后3周记录疼痛、功能能力、关节活动范围和服用的镇痛药情况。患者和进行随访的研究人员对治疗情况不知情。

结果

注射皮质类固醇后,各种类型的疼痛均减轻,但静息时疼痛减轻最为明显。在3周(和12周)随访时疼痛显著减轻。所有方向的关节活动范围均显著增加。注射后功能能力显著改善。我们发现接受局部麻醉剂治疗的患者疼痛未显著缓解,功能能力也未改善。

结论

本研究表明,关节内注射皮质类固醇可能改善髋部骨关节炎患者患侧关节的疼痛和活动范围。

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