Li Li, Dou Xiaofan, Song Xueliang, Wang Fengxian
Center for Rehabilitation Medicine, Department of Orthopedics, Zhejiang Provincial People'S Hospital (Affiliated People'S Hospital, Hangzhou Medical College), No. 158 Shangtang Road, Hangzhou, 310014, Zhejiang, China.
Nursing department, Zhejiang Provincial People'S Hospital (Affiliated People'S Hospital, Hangzhou Medical College), No. 158 Shangtang Road, Hangzhou, 310014, Zhejiang, China.
Curr Pain Headache Rep. 2025 Mar 18;29(1):64. doi: 10.1007/s11916-025-01378-z.
Hip osteoarthritis constitutes a prevalent condition among individuals aged 55 and above, serving as one of the primary triggers for joint discomfort and impairment, and marking a substantial origin of chronic pain particularly affecting the elderly population. Our article provides an exhaustive summary of the mechanisms of action, therapeutic efficacy, and potential adverse consequences associated with novel therapeutic modalities including glucocorticoids, hyaluronic acid, platelet-rich plasma, mesenchymal stem cells, and stromal vascular fraction. Concurrently, we conducted a comprehensive evaluation of the clinical efficacy and potential applications of various medications.
In comparison to physical therapy, oral analgesics, and other nonsurgical modalities, intra-articular injection therapy is characterized by enhanced safety and greater efficacy. Moreover, when contrasted with surgical intervention, intra-articular injection demonstrates a lower degree of invasiveness and incurs fewer adverse reactions. Intra-articular treatments have shown excellent local efficacy while significantly minimizing adverse reactions in patients. These methods hold significant potential for development but require comprehensive research and thorough discussion within the academic community.
髋骨关节炎在55岁及以上人群中普遍存在，是关节不适和功能障碍的主要诱因之一，也是慢性疼痛的重要根源，尤其影响老年人群。本文详尽总结了包括糖皮质激素、透明质酸、富血小板血浆、间充质干细胞和基质血管成分在内的新型治疗方式的作用机制、治疗效果及潜在不良后果。同时，我们对各类药物的临床疗效和潜在应用进行了全面评估。
与物理治疗、口服镇痛药及其他非手术方式相比，关节内注射疗法安全性更高、疗效更佳。此外，与手术干预相比，关节内注射的侵入性更低，不良反应更少。关节内治疗已显示出良好的局部疗效，同时显著减少了患者的不良反应。这些方法具有巨大的发展潜力，但需要学术界进行全面研究和深入探讨。
