Zhu Lan, Lang Jinghe, Chen Juan, Chen Jie
Dept of O/G, Peking Union Medical College Hospital, 100730 Beijing, PR of China.
Int Urogynecol J Pelvic Floor Dysfunct. 2004 Jul-Aug;15(4):272-5. doi: 10.1007/s00192-004-1155-7.
The aim of this study was to determine the relationship of innervation in anterior vaginal epithelium with the etiology of stress urinary incontinence (SUI). Fifty-three biopsy specimens of the anterior vaginal epithelium were obtained from 53 subjects in control, pelvic organ prolapse (POP) and SUI groups. Routine HE staining and immunohistochemical staining for protein gene product 9.5 (PGP9.5) were performed for all specimens. PGP9.5 immunoreactivity was identified in nerve fibers and cells of the epithelium and subepitheliual connective tissue of vagina. The nerve fiber profiles of vaginal epithelium in the SUI/POP groups were significantly lower than those in the control group (P < 0.05). There was no correlation between the nerve fiber profiles and parity in SUI, POP and control groups. Decrease of nerve fiber profiles in anterior vaginal epithelium might lead to the occurrence of SUI.
本研究的目的是确定阴道前壁上皮神经支配与压力性尿失禁（SUI）病因之间的关系。从53名对照、盆腔器官脱垂（POP）和SUI组的受试者中获取了53份阴道前壁上皮活检标本。对所有标本进行常规苏木精-伊红（HE）染色及蛋白基因产物9.5（PGP9.5）免疫组织化学染色。在阴道上皮及上皮下结缔组织的神经纤维和细胞中鉴定出PGP9.5免疫反应性。SUI/POP组阴道上皮的神经纤维数量显著低于对照组（P<0.05）。SUI、POP和对照组的神经纤维数量与产次之间均无相关性。阴道前壁上皮神经纤维数量减少可能导致SUI的发生。
