Crockett Barbara A, Churchill Erik, Davidson Jonathan R T
Department of Psychiatry, Duke University Medical Center, Box 3516, Durham, NC, 27710, USA.
Ann Clin Psychiatry. 2004 Jul-Sep;16(3):127-32. doi: 10.1080/10401230490486972.
This double blind, randomized, parallel, placebo-controlled study investigates whether clonazepam accelerates and/ or increases the overall response in patients with obsessive compulsive disorder (OCD) who are treated with sertraline. Thirty-seven patients were randomized with 20 in the sertraline and clonazepam group and 17 in the sertraline and placebo groups. Male and female outpatients, age 18-65 years, met criteria for a primary diagnosis of obsessive compulsive disorder according to DSM-IV, as determined by the structured clinical MINI interview. Appropriate safety and efficacy parameters were measured throughout the study. The determination of efficacy was based primarily on changes from baseline to the last observation taken through week 12. Analysis revealed no significant difference between groups at endpoint on the main scale.
这项双盲、随机、平行、安慰剂对照研究旨在调查氯硝西泮是否能加速和/或增强接受舍曲林治疗的强迫症（OCD）患者的总体反应。37名患者被随机分组，20名进入舍曲林和氯硝西泮组，17名进入舍曲林和安慰剂组。年龄在18至65岁之间的男性和女性门诊患者，根据DSM-IV标准，经结构化临床MINI访谈确定符合强迫症初步诊断标准。在整个研究过程中测量了适当的安全性和有效性参数。疗效的确定主要基于从基线到第12周最后一次观察的变化。分析显示，在主要量表的终点，两组之间没有显著差异。
