Clarke Laura A, Cassidy Curtis W, Catalano Glenn, Catalano Maria C, Carroll Kathleen M
Department of Psychiatry, New York University, New York, New York, USA.
Ann Clin Psychiatry. 2004 Jul-Sep;16(3):171-5. doi: 10.1080/10401230490487034.
Anticholinergic agents have multiple CNS effects, even when used in therapeutic doses. These can include sedation, amnesia, delirium and, in rare cases, psychosis. While there is some symptom overlap between delirium and psychosis, psychotic patients will have a clear sensorium. We present the case of a 59-year-old male who became psychotic and required hospitalization after the administration of a large anticholinergic load from a smoking cessation clinic. We will review the literature regarding previous cases of anticholinergic medication induced psychosis, discuss treatment options and review the clinical effects of anticholinergic medications.
抗胆碱能药物即使在治疗剂量下使用也会产生多种中枢神经系统效应。这些效应可能包括镇静、失忆、谵妄，在极少数情况下还会导致精神病。虽然谵妄和精神病之间存在一些症状重叠，但精神病患者的意识是清晰的。我们报告一例59岁男性患者，在接受戒烟诊所给予的大量抗胆碱能药物后出现精神病症状并需要住院治疗。我们将回顾关于抗胆碱能药物诱发精神病既往病例的文献，讨论治疗方案并回顾抗胆碱能药物的临床效应。
