Cecha Jószef, Drabek Grzegorz, Błazelonis Adam, Romanowski Wojciech, Zubelewicz-Szkodzińska Barbara
Oddziału Klinicznego Chorób Wewnetrznych w Bytomiu.
Wiad Lek. 2004;57(5-6):255-8.
Statins operate through inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, a key enzyme which regulates intracellular cholesterol synthesis. Their so-called pleiotropic effects incorporate alterations of endothelial function, inflammation, coagulation and plaque stability. This review will focus on statins regulation role in inflammation.
他汀类药物通过抑制3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶发挥作用，该酶是调节细胞内胆固醇合成的关键酶。它们所谓的多效性作用包括内皮功能、炎症、凝血和斑块稳定性的改变。本综述将聚焦于他汀类药物在炎症中的调节作用。
