肺炎链球菌中互补uvr - 402的基因结构：与大肠杆菌uvrB及藤黄微球菌中同源基因的同源性
Structure of the gene complementing uvr-402 in Streptococcus pneumoniae: homology with Escherichia coli uvrB and the homologous gene in Micrococcus luteus.
作者信息
Sicard N, Oreglia J, Estevenon A M
机构信息
Centre National de la Recherche Scientifique, Université Paul Sabatier, Toulouse, France.
出版信息
J Bacteriol. 1992 Apr;174(7):2412-5. doi: 10.1128/jb.174.7.2412-2415.1992.
Abstract
The repair ability for UV-induced damage observed for Streptococcus pneumoniae proceeds through a system similar to the Uvr-dependent system in Escherichia coli. The DNA sequence of a gene complementing uvr-402, a mutation conferring UV sensitivity, was determined. Alignments of the deduced amino acid sequence revealed an extensive sequence homology of 55% with the UvrB protein of E. coli and 59% with the UvrB-homologous protein of Micrococcus luteus. Nucleotide-binding site consensus was observed. The high conservation of the uvrB-like gene among these three species suggests that the role of the UvrB protein and excision repair in general might be very important for cell survival.
摘要
肺炎链球菌对紫外线诱导损伤的修复能力是通过一个类似于大肠杆菌中依赖Uvr的系统进行的。确定了一个能互补uvr - 402（一种导致紫外线敏感性的突变）的基因的DNA序列。推导的氨基酸序列比对显示，与大肠杆菌的UvrB蛋白有55%的广泛序列同源性，与藤黄微球菌的UvrB同源蛋白有59%的同源性。观察到核苷酸结合位点共有序列。这三个物种中类uvrB基因的高度保守表明，一般来说，UvrB蛋白和切除修复的作用可能对细胞存活非常重要。
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