Shah Akeel A, Sjovold Travis, Treit Dallas
Department of Psychology, University of Alberta P217 Biological Sciences Building, Edmonton, AB, Canada T6G 2E9.
Brain Res. 2004 Nov 26;1028(1):112-5. doi: 10.1016/j.brainres.2004.08.061.
This study examined the effects of infusions of a direct GABA(A) receptor agonist, muscimol, into the medial prefrontal cortex (MPFC), on fear behavior measured in the elevated plus-maze and shock-probe burying tests. Bilateral infusions of either a 0.175 or 4 nmol/0.5 microl dose of muscimol increased the percentage of entries and time spent in the open arms, and attenuated shock-probe burying. These findings indicate that intra-MPFC infusions of muscimol induce anxiolysis, and suggest that the direct stimulation of MPFC GABA(A) receptors attenuates fear-related behavior.
本研究检测了向内侧前额叶皮质（MPFC）注射直接γ-氨基丁酸A（GABA(A)）受体激动剂蝇蕈醇对高架十字迷宫和电击探针掩埋试验中恐惧行为的影响。双侧注射0.175或4纳摩尔/0.5微升剂量的蝇蕈醇增加了进入开放臂的百分比和在开放臂停留的时间，并减弱了电击探针掩埋行为。这些结果表明，向MPFC内注射蝇蕈醇可诱发抗焦虑作用，并提示直接刺激MPFC的GABA(A)受体可减弱与恐惧相关的行为。
