Schulz-Klaus Brigitte, Fendt Markus, Schnitzler Hans-Ulrich
Tierphysiologie, Zoologisches Institut, Universität Tübingen, Germany.
Behav Brain Res. 2005 Sep 8;163(2):168-73. doi: 10.1016/j.bbr.2005.04.022.
The present study investigated whether the rostral perirhinal cortex is involved in aversive information processing, particularly in unconditioned fear (anxiety). We temporarily inactivated the rostral perirhinal cortex by local injections of the GABA(A) agonist muscimol (0.0, 1.1, and 4.4 nmol/0.5 microl) and tested whether these injections affected the behavior of rats in the elevated plus-maze and in the yohimbine-enhanced startle test. Temporary inactivation of the rostral perirhinal cortex increased the number of open arm entries and the open arm ratio in the elevated plus-maze. In addition, startle response enhancement caused by the anxiogenic drug yohimbine was reduced by perirhinal cortex inactivation. Taken together, these data clearly show that the rostral perirhinal cortex is involved in the processing of emotional stimuli and is critical for the expression of unconditioned fear (anxiety).
本研究调查了吻侧内嗅皮质是否参与厌恶信息处理，特别是在无条件恐惧（焦虑）方面。我们通过局部注射GABA(A)激动剂蝇蕈醇（0.0、1.1和4.4纳摩尔/0.5微升）暂时使吻侧内嗅皮质失活，并测试这些注射是否会影响大鼠在高架十字迷宫和育亨宾增强惊吓试验中的行为。吻侧内嗅皮质的暂时失活增加了高架十字迷宫中进入开放臂的次数和开放臂比例。此外，内嗅皮质失活降低了致焦虑药物育亨宾引起的惊吓反应增强。综上所述，这些数据清楚地表明，吻侧内嗅皮质参与情绪刺激的处理，并且对于无条件恐惧（焦虑）的表达至关重要。
