活体肾供体的风险及生活质量变化

Risks and quality-of-life changes in living kidney donors.

作者信息

Chen C-H, Chen Y, Chiang Y-J, Wu C-T, Chen H-W, Chu S-H

机构信息

Department of Urology, Evernew General Hospital, Taoyuan, Taiwan.

出版信息

Transplant Proc. 2004 Sep;36(7):1920-1. doi: 10.1016/j.transproceed.2004.08.016.

DOI:10.1016/j.transproceed.2004.08.016

PMID:15518699

Abstract

INTRODUCTION

Although the benefits of living donor organs for recipients are well documented, the risks and quality-of-life changes in living kidney donors are seldom reported.

METHODS

From July 1992 to June 2002, all living kidney donors underwent regular follow-up at our hospital. The MOS 36-item short-form health survey (SF-36), a standardized questionnaire to measure quality of life, was used in this study. Furthermore, donor renal function and associate complications were assessed.

RESULTS

Seventeen donors answered the questionnaire, including eight men and nine women of mean age of 41 years (range = 25 to 56). No perioperative mortality was noted. No proteinuria or hematuria was found during long-term follow-up. The mean serum creatinine level was 0.95 +/- 0.22 mg/dL before the operation. The postoperative mean serum creatinine levels at 6 months, 1 year, and 3 years were 1.22 +/- 0.34, 1.19 +/- 0.20, and 1.29 +/- 0.21 mg/dL, respectively. Two cases underwent scar revision and one complained long-term wound pain for more than 1 year. One donor became depressed because of graft failure in her son. The SF-36 scores were 84.4 +/- 4.4 (physical function), 84.0 +/- 4.7 (role-physical), 78.4 +/- 8.0 (body pain), 81.5 +/- 5.9 (general health), 83.2 +/- 3.7 (vitality), 83.9 +/- 5.9 (social functioning), 79.9 +/- 4.1 (role-emotional), and 78.6 +/- 2.3 (mental health), respectively.

CONCLUSION

The quality-of-life changes and risks after donation are low; most donors are concerned about cosmetic problems and pain-related scar formation.

摘要

引言

尽管活体供体器官对受者的益处已有充分记录，但活体肾供体的风险及生活质量变化却鲜有报道。

方法

1992年7月至2002年6月，所有活体肾供体在我院接受定期随访。本研究采用MOS 36项简短健康调查问卷（SF - 36），这是一种用于测量生活质量的标准化问卷。此外，还对供体肾功能及相关并发症进行了评估。

结果

17名供体回答了问卷，其中包括8名男性和9名女性，平均年龄41岁（范围为25至56岁）。未观察到围手术期死亡情况。长期随访期间未发现蛋白尿或血尿。术前平均血清肌酐水平为0.95±0.22mg/dL。术后6个月、1年和3年的平均血清肌酐水平分别为1.22±0.34、1.19±0.20和1.29±0.21mg/dL。2例接受了瘢痕修复，1例抱怨长期伤口疼痛超过1年。1名供体因儿子的移植肾失败而变得抑郁。SF - 36评分分别为：生理功能84.4±4.4，生理角色84.0±4.7，身体疼痛78.4±8.0，总体健康81.5±5.9，活力83.2±3.7，社会功能83.9±5.9，情感角色79.9±4.1，心理健康78.6±2.3。