Raska Ivan, Koberna Karel, Malínský Jan, Fidlerová Helena, Masata Martin
1st Faculty of Medicine, Charles University and Department of Cell Biology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 12800 Prague 2, Czech Republic.
Biol Cell. 2004 Oct;96(8):579-94. doi: 10.1016/j.biolcel.2004.04.015.
Ribosome biogenesis is a highly dynamic, steady-state nucleolar process that involves synthesis and maturation of rRNA, its transient interactions with non-ribosomal proteins and RNPs and assembly with ribosomal proteins. In the few years of the 21st century, an exciting progress in the molecular understanding of rRNA and ribosome biogenesis has taken place. In this review, we discuss the recent results on the regulation of rRNA synthesis in relation to the functional organization of the nucleolus, and put an emphasis on the situation encountered in mammalian somatic cells.
核糖体生物发生是一个高度动态的稳态核仁过程，涉及rRNA的合成与成熟、其与非核糖体蛋白和核糖核蛋白的瞬时相互作用以及与核糖体蛋白的组装。在21世纪的头几年，对rRNA和核糖体生物发生的分子理解取得了令人兴奋的进展。在这篇综述中，我们讨论了与核仁功能组织相关的rRNA合成调控的最新研究结果，并着重介绍了哺乳动物体细胞中遇到的情况。
