Krutmann J, Czech W, Diepgen T, Niedner R, Kapp A, Schöpf E
Department of Dermatology, University of Freiburg, F.R.G.
J Am Acad Dermatol. 1992 Feb;26(2 Pt 1):225-30. doi: 10.1016/0190-9622(92)70031-a.
Besides glucocorticosteroids, there is currently no known effective therapy for patients with acute atopic dermatitis.
The therapeutic effectiveness of high-dose UVA1 irradiation in the management of patients with acute exacerbation of atopic dermatitis was examined.
Patients in the high-dose UVA1 group (n = 15) were irradiated with 130 joules/cm2 UVA1; the control group (n = 10) was treated with UVA-UVB therapy in a minimal erythema dose-dependent manner (total number of treatments 15).
High-dose UVA1 irradiation was found to induce a significant clinical improvement of atopic dermatitis (p less than 0.001). In comparison with UVA-UVB therapy, significant differences in favor of high-dose UVA1 were observed (p less than 0.01). High-dose UVA1, but not UVA-UVB treatment, significantly reduced the elevated serum level of eosinophil cationic protein in patients with atopic dermatitis (p less than 0.003).
These studies indicate that high-dose UVA1 irradiation may represent a novel phototherapeutic modality for the treatment of patients with an acute exacerbation of atopic dermatitis.
除糖皮质激素外，目前尚无已知的针对急性特应性皮炎患者的有效治疗方法。
研究高剂量UVA1照射对特应性皮炎急性加重期患者的治疗效果。
高剂量UVA1组（n = 15）患者接受130焦耳/平方厘米的UVA1照射；对照组（n = 10）采用依最小红斑量的方式进行UVA-UVB治疗（治疗总次数为15次）。
发现高剂量UVA1照射可使特应性皮炎的临床症状显著改善（p < 0.001）。与UVA-UVB治疗相比，观察到高剂量UVA1具有显著优势（p < 0.01）。高剂量UVA1治疗可显著降低特应性皮炎患者血清中嗜酸性粒细胞阳离子蛋白升高的水平，而UVA-UVB治疗则无此效果（p < 0.003）。
这些研究表明，高剂量UVA1照射可能是治疗特应性皮炎急性加重期患者的一种新型光疗方法。
