分子生物学中的还原论与复杂性。科学家们如今拥有了揭示生物学奥秘并克服还原论局限性的工具。
Reductionism and complexity in molecular biology. Scientists now have the tools to unravel biological and overcome the limitations of reductionism.
作者信息
Van Regenmortel Marc H V
机构信息
Ecole Supérieure de Biotechnologie de Strasbourg at the Centre National de la Recherche Scientifique (CNRS) in Strasbourg, France.
出版信息
EMBO Rep. 2004 Nov;5(11):1016-20. doi: 10.1038/sj.embor.7400284.
Abstract
Scientists now have the tools to unravel biological complexity and overcome the limitations of reductionism
摘要
科学家们现在拥有了解开生物复杂性并克服还原论局限性的工具。
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Vaccine. 2004 Sep 9;22(27-28):3523-9. doi: 10.1016/j.vaccine.2004.05.006.
2
Bio-ontologies-fast and furious.生物本体论——快速且迅猛。
Nat Biotechnol. 2004 Jun;22(6):773-4. doi: 10.1038/nbt0604-773.
3
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J Mol Recognit. 2004 May-Jun;17(3):145-8. doi: 10.1002/jmr.674.
4
Conformational changes associated with protein-protein interactions.与蛋白质-蛋白质相互作用相关的构象变化。
Curr Opin Struct Biol. 2004 Feb;14(1):104-9. doi: 10.1016/j.sbi.2004.01.005.
5
Biotechnology: identifying advances from the hype.生物技术：从炒作中识别进展。
Nat Rev Drug Discov. 2004 Feb;3(2):177-83. doi: 10.1038/nrd1309.
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Nat Immunol. 2004 Mar;5(3):233-6. doi: 10.1038/ni0304-233.
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