Cascio A, Iaria C, Campennì A, Blandino A, Baldari S
Scuola di Specializzazione in Malattie Infettive, Dipartimento di Patologia Umana, Università di Messina, Messina, Italy.
Clin Microbiol Infect. 2004 Nov;10(11):1020-2. doi: 10.1111/j.1469-0691.2004.00961.x.
Twenty-two patients with suspected brucellar spondylitis were investigated to evaluate the possible diagnostic role of Sulesomab, a (99m)Tc-antigranulocyte antibody Fab' fragment. Sensitivity and specificity were compared with those of magnetic resonance imaging (MRI). Skeletal involvement was detected by MRI in 11 cases, while leukoscintigraphy indicated normal vertebral uptake in seven of these patients, increased uptake in two patients, and decreased uptake in two patients. Leukoscintigraphy of the 11 patients negative by MRI demonstrated increased uptake in two cases. The sensitivity and specificity of leukoscintigraphy were 27.2% and 81.1%, respectively. Based on these results, leukoscintigraphy is not indicated for the management of patients with suspected brucellar spondylitis.
对22例疑似布鲁氏菌性脊柱炎患者进行了研究，以评估(99m)Tc抗粒细胞抗体Fab'片段苏利索单抗的可能诊断作用。将其敏感性和特异性与磁共振成像（MRI）的敏感性和特异性进行比较。MRI检测到11例骨骼受累，而白细胞闪烁扫描显示其中7例患者椎体摄取正常，2例患者摄取增加，2例患者摄取减少。MRI检查为阴性的11例患者的白细胞闪烁扫描显示2例摄取增加。白细胞闪烁扫描的敏感性和特异性分别为27.2%和81.1%。基于这些结果，白细胞闪烁扫描不适合用于疑似布鲁氏菌性脊柱炎患者的管理。
