Bagary Manjinder S, Hutton Samuel B, Symms Mark R, Barker Gareth J, Mutsatsa Stanley H, Barnes Thomas R E, Joyce Eileen M, Ron Maria A
Institute of Neurology, University College London, Queens Square, London WC1N 3BG, United Kingdom.
Biol Psychiatry. 2004 Nov 1;56(9):620-7. doi: 10.1016/j.biopsych.2004.08.017.
Smooth pursuit and antisaccade abnormalities are well documented in schizophrenia, but their neuropathological correlates remain unclear.
In this study, we used statistical parametric mapping to investigate the relationship between oculomotor abnormalities and brain structure in a sample of first-episode schizophrenia patients (n = 27). In addition to conventional volumetric magnetic resonance imaging, we also used magnetization transfer ratio, a technique that allows more precise tissue characterization.
We found that smooth pursuit abnormalities were associated with reduced magnetization transfer ratio in several regions, predominantly in the right prefrontal cortex. Antisaccade errors correlated with gray matter volume in the right medial superior frontal cortex as measured by conventional magnetic resonance imaging but not with magnetization transfer ratio.
These preliminary results demonstrate that specific structural abnormalities are associated with abnormal eye movements in schizophrenia.
精神分裂症患者的平稳跟踪和反扫视异常已有充分记录，但其神经病理学相关性仍不清楚。
在本研究中，我们使用统计参数映射来研究首发精神分裂症患者样本（n = 27）中眼球运动异常与脑结构之间的关系。除了传统的容积磁共振成像外，我们还使用了磁化传递比率，这是一种能够进行更精确组织特征描述的技术。
我们发现，平稳跟踪异常与多个区域的磁化传递比率降低有关，主要是右侧前额叶皮质。通过传统磁共振成像测量，反扫视错误与右侧内侧额上回的灰质体积相关，但与磁化传递比率无关。
这些初步结果表明，精神分裂症中特定的结构异常与异常眼动有关。
