Deitsch Kirk W, Hviid Lars
Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, W-704, Box 62, New York, NY 10021, USA.
Trends Parasitol. 2004 Dec;20(12):562-6. doi: 10.1016/j.pt.2004.09.002.
The first Molecular Approaches to Malaria meeting was held 2-5 February 2000 in Lorne, Australia. Following the meeting, Brian Cooke, Mats Wahlgren and Ross Coppel predicted that research into the molecular details of the mechanisms behind sequestration of parasitized erythrocytes would "become increasingly more complicated, with further interactions, receptors, ligands and functional domains". Furthermore, they cautioned that "the challenge will be not to lose ourselves in the molecular detail, but remain focused on the role of [the var genes and other multigene families] in pathogenesis of malaria". We contemplate on these statements, following the recent second Molecular Approaches to Malaria meeting, which was held at the same venue on 2-5 February 2004.
首届疟疾分子研究方法会议于2000年2月2日至5日在澳大利亚洛恩举行。会议之后，布莱恩·库克、马茨·瓦尔格伦和罗斯·科佩尔预测，对被寄生红细胞滞留背后机制的分子细节研究“将会因更多的相互作用、受体、配体和功能域而变得愈发复杂”。此外，他们还告诫说，“挑战在于不要迷失在分子细节中，而要始终专注于[var基因和其他多基因家族]在疟疾发病机制中的作用”。在近期于2004年2月2日至5日在同一地点举行的第二届疟疾分子研究方法会议之后，我们思考了这些言论。
