MacLullich Alasdair M J, Edmond C Louise, Ferguson Karen J, Wardlaw Joanna M, Starr John M, Seckl Jonathan R, Deary Ian J
Geriatric Medicine Unit, University of Edinburgh, Room SU220, The Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK.
Brain Cogn. 2004 Dec;56(3):344-8. doi: 10.1016/j.bandc.2004.08.001.
Cerebellar volumes show small positive correlations with cognitive ability in young adults, but no studies have examined this relationship in older adults. Furthermore, no studies have examined relationships between sizes of subareas of the cerebellum and cognitive ability. We hypothesized that size of the two areas of the neocerebellar vermis would correlate with a battery of eight cognitive tests in 50 men aged 65-70. Size of the neocerebellar areas of the vermis correlated positively with several cognitive tests (r's=.29-.37, p<.05), whilst sizes of other parts of the vermis did not correlate with any cognitive tests. Total cerebellar volumes correlated significantly with a test of nonverbal reasoning (r=.030, p=.42). These findings suggest a specific association of neocerebellar vermis size with variations in cognitive ability in older adults.
在年轻成年人中，小脑体积与认知能力呈微弱正相关，但尚无研究在老年人中检验这种关系。此外，也没有研究考察过小脑各亚区大小与认知能力之间的关系。我们假设，在50名65 - 70岁男性中，新小脑蚓部两个区域的大小与八项认知测试相关。新小脑蚓部区域的大小与多项认知测试呈正相关（r值 = 0.29 - 0.37，p < 0.05），而蚓部其他部分的大小与任何认知测试均无相关性。小脑总体积与一项非言语推理测试显著相关（r = 0.30，p = 0.42）。这些发现表明，新小脑蚓部大小与老年人认知能力的变化存在特定关联。
