Behbehani Raed, Sergott Robert C, Savino Peter J
Neuroophthalmology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Curr Opin Ophthalmol. 2004 Dec;15(6):479-82. doi: 10.1097/01.icu.0000144388.89867.03.
Orbital radiotherapy has been one of the primary treatment modalities for moderate to severe thyroid-related orbitopathy. In this review the authors discuss the role of orbital radiotherapy in this disease with particular emphasis on questions raised by recent studies.
Despite its widespread use, until recently there have been few well-designed, randomized clinical trials on the role of orbital radiotherapy for thyroid-related orbitopathy. Although most the literature points to a favorable effect of orbital radiotherapy, recent studies have provided us with conflicting results.
Orbital radiotherapy remains a safe and a widely used treatment option for severe and progressive thyroid-related orbitopathy. More randomized clinical trials are needed, especially to examine the role of orbital radiotherapy for severe thyroid-related orbitopathy characterized by severe congestion and/or compressive optic neuropathy with and without the use of corticosteroids. There is a wide consensus among clinicians that this subgroup of patients is the most frequent one to which orbital radiotherapy is offered.
眼眶放射治疗一直是中重度甲状腺相关性眼病的主要治疗方式之一。在本综述中，作者讨论了眼眶放射治疗在该疾病中的作用，特别强调了近期研究所提出的问题。
尽管眼眶放射治疗被广泛应用，但直到最近，关于其在甲状腺相关性眼病中作用的精心设计的随机临床试验仍很少。虽然大多数文献指出眼眶放射治疗具有良好效果，但近期研究却给出了相互矛盾的结果。
对于严重且进行性的甲状腺相关性眼病，眼眶放射治疗仍是一种安全且广泛应用的治疗选择。需要更多的随机临床试验，尤其是要研究眼眶放射治疗在伴有或不伴有使用糖皮质激素的、以严重充血和/或压迫性视神经病变为特征的严重甲状腺相关性眼病中的作用。临床医生们普遍认为，这一亚组患者是最常接受眼眶放射治疗的人群。
