Macaigne Gilles, Boivin Jean-François, Auriault Marie-Luce, Deplus Renaud
Service d'hépato-gastroentérologie, Hôpital de Lagny-Marne-la-Vallée, 77405 Lagny-sur-Marne Cedex.
Gastroenterol Clin Biol. 2004 Oct;28(10 Pt 1):913-6. doi: 10.1016/s0399-8320(04)95158-5.
Tropical sprue (TS) is a postinfective tropical malabsorption that occurs in tropical countries. TS is associated with a persisting colonization of the small-intestine lumen by enterotoxinogenic bacteria that cause subsequent enterocyte damage affecting all or part of the small-intestine. We report two cases of TS that occurred in inhabitants of Paris area returned from endemic areas. The first observation concerned a 76-year old woman admitted for anorexia, loss of 20 kg and anemia. The second observation concerned a 53-year old man referred for chronic diarrhea and loss of 40 kg within 4 years. In both cases, duodenal lesions consisted of subtotal and total villous atrophy with prominent infiltration of the damaged surface epithelium with lymphocytes and infiltrate of lymphocytes and plasma cells of the lamina propria. The two patients recovered under antibiotics, confirming the diagnosis of TS.
热带口炎性腹泻（TS）是一种发生在热带国家的感染后热带吸收不良疾病。TS与产肠毒素细菌在小肠腔内持续定植有关，这些细菌会导致随后的肠上皮细胞损伤，影响全部或部分小肠。我们报告了两例发生在从流行地区返回的巴黎地区居民身上的TS病例。第一例是一名76岁女性，因厌食、体重减轻20公斤和贫血入院。第二例是一名53岁男性，因慢性腹泻和4年内体重减轻40公斤前来就诊。在这两例病例中，十二指肠病变均表现为部分和完全绒毛萎缩，受损表面上皮有明显的淋巴细胞浸润以及固有层淋巴细胞和浆细胞浸润。两名患者在接受抗生素治疗后康复，证实了TS的诊断。
