Wild Klemens, Halic Mario, Sinning Irmgard, Beckmann Roland
Biochemie-Zentrum der Universität Heidelberg, Im Neuenheimer Feld 328, D-69120 Heidelberg, Germany.
Nat Struct Mol Biol. 2004 Nov;11(11):1049-53. doi: 10.1038/nsmb853.
Cotranslational targeting directly couples synthesis of proteins to their translocation across or insertion into membranes. The signal recognition particle (SRP) and its membrane-bound receptor facilitate the targeting of the translation machinery, the ribosome, via recognition of a signal sequence in the nascent peptide chain. By combining structures of free and ribosome-bound SRP we derive a structural model describing the dynamic nature of SRP when it meets the ribosome.
共翻译靶向直接将蛋白质的合成与其跨膜转运或插入膜中相偶联。信号识别颗粒（SRP）及其膜结合受体通过识别新生肽链中的信号序列，促进翻译机器即核糖体的靶向定位。通过结合游离状态和与核糖体结合状态的SRP的结构，我们推导了一个描述SRP与核糖体相遇时动态性质的结构模型。
