Affara Nesrine I, Robertson Fredika M
Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA.
In Vivo. 2004 Sep-Oct;18(5):525-42.
This review focuses on vascular endothelial growth factors (VEGF), a group of structurally-related proteins that serve as key growth factors for tumor-associated angiogenesis. Pathways induced by VEGF proteins that regulate biological functions of key cell types involved in tumor angiogenesis, including vascular endothelial cells, pericytes and tumor cells, are discussed. Strategies that are currently being developed and tested based on the emerging definitions of the roles of the multiple cell types involved in tumor vessel development, their selective production of VEGF-related proteins and other pro-angiogenic growth factors, their expression of associated receptors as well as identification of signal transduction pathways involved in VEGF-induced tumor survival and tumor-associated angiogenesis will be reviewed.
本综述聚焦于血管内皮生长因子（VEGF），这是一组结构相关的蛋白质，是肿瘤相关血管生成的关键生长因子。文中讨论了VEGF蛋白所诱导的信号通路，这些通路调节参与肿瘤血管生成的关键细胞类型（包括血管内皮细胞、周细胞和肿瘤细胞）的生物学功能。基于参与肿瘤血管发育的多种细胞类型的作用新定义、它们对VEGF相关蛋白和其他促血管生成生长因子的选择性产生、它们相关受体的表达以及对VEGF诱导的肿瘤存活和肿瘤相关血管生成中涉及的信号转导通路的鉴定，目前正在开发和测试的策略也将在本文中进行综述。
