Barańska Patrycja, Jerczyńska Hanna, Pawłowska Zofia
Department of Molecular and Medical Biophysics, Institute of Physiology and Biochemistry, Medical University of Lodz, 6/8 Mazowiecka St., 92-215 Lodz, Poland.
Postepy Biochem. 2005;51(1):12-21.
Vascular endothelial cell growth factor (VEGF), originally described as a vascular permeability factor, is currently known as one of the main factors which regulate angiogenesis. It plays an important role in the regulation of normal as well as pathological angiogenesis. In this paper we try to shortly review the actual knowledge on VEGF protein family, its expression, VEGF receptors and role of VEGF in signal transduction. The aim of this review is also to summarize recent achievements in research on biological functions of vascular endothelial growth factor and their clinical applications.
血管内皮细胞生长因子（VEGF）最初被描述为一种血管通透因子，目前被认为是调节血管生成的主要因子之一。它在正常以及病理性血管生成的调节中发挥着重要作用。在本文中，我们试图简要回顾关于VEGF蛋白家族、其表达、VEGF受体以及VEGF在信号转导中的作用的现有知识。本综述的目的还在于总结血管内皮生长因子生物学功能研究及其临床应用的最新成果。
