Smiarowska Małgorzata, Krzyzanowska-Swiniarska Barbara, Lisiecka Agata, Letkiewicz Magdalena, Pilarska Krystyna, Horodnicki Jan
Katedry i Kliniki Psychiatrii w Szczecinie.
Psychiatr Pol. 2004 Sep-Oct;38(5):883-94.
In this research psychic and somatic symptoms related to disturbances of hypothalamus-hypophysis-peripheral regulation which may occur in the schizophrenic process were analysed. Authors discussed the problem of relations between hypothalamus neuroregulation and pathogenesis of endocrine disturbances which suggest the organic cause of obesity, hirsutism and secondary amenorrhea among women diagnosed with paranoid schizophrenia. Actual antipsychotic pharmacological treatment, including some side-effects: the metabolic (obesity) and the endocrine (hyperprolactinemia) ones were considered. The authors conclude that endocrine disorders which are connected with hypothalamus disfunction (sleeping, eating and reproductive functions) may reach the psychotic symptoms and treating them influences at the same time some endocrine changes. The estimation of PRL release in a test of stimulation with metoclopramide can be a sensitive (though not specific) test of dopaminergic activity in tuberous--infundibulum pathway and may be used to control the treatment.
在本研究中，分析了与下丘脑 - 垂体 - 外周调节紊乱相关的精神和躯体症状，这些症状可能出现在精神分裂症病程中。作者讨论了下丘脑神经调节与内分泌紊乱发病机制之间的关系问题，这些关系提示了被诊断为偏执型精神分裂症的女性中肥胖、多毛症和继发性闭经的器质性病因。考虑了实际的抗精神病药物治疗，包括一些副作用：代谢性（肥胖）和内分泌性（高催乳素血症）副作用。作者得出结论，与下丘脑功能障碍（睡眠、饮食和生殖功能）相关的内分泌紊乱可能导致精神症状，而对这些症状的治疗同时会影响一些内分泌变化。在甲氧氯普胺刺激试验中对催乳素释放的评估可以是结节 - 漏斗途径中多巴胺能活性的敏感（尽管不是特异性）试验，并且可用于控制治疗。
