Consoli Grazia M L, Cunsolo Francesca, Geraci Corrada, Sgarlata Valentina
Istituto di Chimica Biomolecolare, Sezione di Catania CNR, Via del Santuario 110, I-95028 Valverde (CT), Italy.
Org Lett. 2004 Nov 11;6(23):4163-6. doi: 10.1021/ol0485767.
Novel calix[4 or 8]arene-based glycoconjugates exposing terminal N-acetyl-D-glucosamine clusters have been synthesized using amino acid-calixarenes as building blocks. The obtained glycosamino acid-calixarenes 9b-14b have lectin-binding ability and amplified inhibitory effects on erythrocyte agglutination induced by wheat germ (Triticum vulgaris) agglutinin (WGA). The inhibitory ability is dependent on the presence of the spacer and on the shape and rigidity of the calixarene skeleton.
以氨基酸杯芳烃为构建单元，合成了具有末端N - 乙酰 - D - 葡糖胺簇的新型杯[4或8]芳烃基糖缀合物。所得到的糖基氨基酸杯芳烃9b - 14b具有凝集素结合能力，并对小麦胚（普通小麦）凝集素（WGA）诱导的红细胞凝集具有增强的抑制作用。抑制能力取决于间隔基的存在以及杯芳烃骨架的形状和刚性。
