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用于手性分子识别的新型固有手性杯[4]芳烃的设计

Design of a novel inherently chiral calix[4]arene for chiral molecular recognition.

作者信息

Shirakawa Seiji, Moriyama Akihiro, Shimizu Shoichi

机构信息

Department of Applied Molecular Chemistry and High Technology Research Center, College of Industrial Technology, Nihon University, Narashino, Chiba, 275-8575, Japan.

出版信息

Org Lett. 2007 Aug 2;9(16):3117-9. doi: 10.1021/ol071249p. Epub 2007 Jul 6.

DOI:10.1021/ol071249p
PMID:17616144
Abstract

A newly designed inherently chiral calix[4]arene was synthesized and resolved to an optically pure form. Enantiomeric recognition ability of the chiral calix[4]arene was examined using 1H NMR experiments with mandelic acid. In addition, the chiral calix[4]arene was applied to asymmetric reactions, as an organocatalyst.

摘要

合成了一种新设计的固有手性杯[4]芳烃，并将其拆分为光学纯形式。使用扁桃酸通过1H NMR实验研究了手性杯[4]芳烃的对映体识别能力。此外，手性杯[4]芳烃作为有机催化剂应用于不对称反应。

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