通过铜（I）催化的三组分反应，微波辅助点击化学合成1,4-二取代的1,2,3-三唑。
A microwave-assisted click chemistry synthesis of 1,4-disubstituted 1,2,3-triazoles via a copper(I)-catalyzed three-component reaction.
作者信息
Appukkuttan Prasad, Dehaen Wim, Fokin Valery V, Van der Eycken Erik
机构信息
Department of Chemistry, University of Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.
出版信息
Org Lett. 2004 Nov 11;6(23):4223-5. doi: 10.1021/ol048341v.
PMID:15524448
Abstract
A microwave-assisted three-component reaction was used to prepare a series of 1,4-disubstituted-1,2,3-triazoles from corresponding alkyl halides, sodium azide, and alkynes. This procedure eliminates the need to handle organic azides, as they are generated in situ, making this already powerful click process even more user-friendly and safe.
摘要
采用微波辅助三组分反应，由相应的卤代烃、叠氮化钠和炔烃制备了一系列1,4 - 二取代 - 1,2,3 - 三唑。该方法无需处理有机叠氮化物，因为它们是原位生成的，使得这个原本强大的点击反应过程更加用户友好和安全。
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