Clark D E, Hurst P R, Myers D B, Spears G F
Anatomy Department, University of Otago, Dunedin, New Zealand.
J Reprod Fertil. 1992 Jan;94(1):169-75. doi: 10.1530/jrf.0.0940169.
Implantation and non-implantation sites were dissected into myometrial and stromal components; a decidual/embryonic region was obtained on Days 7 and 8 of pregnancy. The concentration of collagen (as a percentage of the dry weight of tissue), measured by hydroxyproline analysis, was significantly lower in the implantation regions than in the non-implant regions in all areas studied. The concentrations in the antimesometrial myometrium and stroma of the implantation region remained the same over the days studied. In contrast, the mesometrial collagen concentration in the implantation region declined from Day 6 to Day 8 of pregnancy. Collagen concentration was low within the decidual/embryonic tissue on Days 7 and 8 of pregnancy. Remodelling of collagen within the embryonic area appears to be an important feature of the uterine response to implantation in rats.
将着床部位和未着床部位解剖为子宫肌层和基质成分；在妊娠第7天和第8天获取蜕膜/胚胎区域。通过羟脯氨酸分析测定的胶原蛋白浓度（占组织干重的百分比），在所研究的所有区域中，着床区域均显著低于未着床区域。在所研究的天数内，着床区域的子宫系膜对侧子宫肌层和基质中的浓度保持不变。相比之下，着床区域的子宫系膜胶原蛋白浓度在妊娠第6天至第8天下降。妊娠第7天和第8天，蜕膜/胚胎组织内的胶原蛋白浓度较低。胚胎区域内胶原蛋白的重塑似乎是大鼠子宫对着床反应的一个重要特征。
