微小RNA指导不对称DNA修饰，从而引导不对称器官的形成。

MicroRNAs guide asymmetric DNA modifications guiding asymmetric organs.

作者信息

Eshed Yuval, Bowman John L

机构信息

Department of Plant Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel.

出版信息

Dev Cell. 2004 Nov;7(5):629-30. doi: 10.1016/j.devcel.2004.10.011.

DOI:10.1016/j.devcel.2004.10.011

PMID:15525522

Abstract

In plants and animals, microRNAs have been shown to regulate target genes by inhibiting translation or altering target mRNA stability. In this issue of Developmental Cell, Bao et al. extend the known mechanisms of action of microRNAs to RNA-directed DNA methylation, a mechanism previously associated only with siRNA-mediated gene silencing.

摘要

在植物和动物中，微小RNA已被证明可通过抑制翻译或改变靶标信使核糖核酸（mRNA）稳定性来调控靶标基因。在本期《发育细胞》中，鲍等人将微小RNA已知的作用机制扩展到了RNA指导的DNA甲基化，这是一种以前仅与小干扰RNA（siRNA）介导的基因沉默相关的机制。