肽YY与食欲控制。

Peptide YY and appetite control.

作者信息

McGowan B M C, Bloom S R

机构信息

Department of Metabolic Medicine, Imperial College Faculty of Medicine, 6th Floor Commonwealth Building, Hammersmith Campus, DuCane Road, London W12 0NN, UK.

出版信息

Curr Opin Pharmacol. 2004 Dec;4(6):583-8. doi: 10.1016/j.coph.2004.06.007.

DOI:10.1016/j.coph.2004.06.007

PMID:15525548

Abstract

Peptide YY (PYY) is an important gut hormone synthesized and secreted by the gastrointestinal tract. Peripheral administration of PYY(3-36), one of the circulating forms of PYY, is known to inhibit food intake. This anorexigenic effect is masked by stress inhibition of appetite, and it is therefore important for animals to be thoroughly acclimatised for PYY(3-36) to be effective. Evidence suggests that PYY(3-36) acts via the hypothalamic Y(2) receptor. Levels of the anorexigenic hormone PYY(3-36) are low in overweight volunteers and could provide an important therapeutic avenue in the quest to combat the obesity epidemic.

摘要

肽YY（PYY）是一种由胃肠道合成并分泌的重要肠道激素。已知外周给予PYY的循环形式之一PYY（3-36）可抑制食物摄入。这种食欲抑制作用会被应激对食欲的抑制所掩盖，因此让动物充分适应环境以使PYY（3-36）有效发挥作用很重要。有证据表明PYY（3-36）通过下丘脑Y（2）受体发挥作用。超重志愿者体内食欲抑制激素PYY（3-36）的水平较低，这可能为对抗肥胖流行提供一条重要的治疗途径。