Ressiniotis Thomas, Griffiths Philip G, Birch Michael, Keers Sharon M, Chinnery Patrick F
Department of Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.
Mol Vis. 2004 Oct 28;10:805-7.
Primary open angle glaucoma (POAG) is a major cause of late onset visual failure of unknown etiology. Recent genetic association studies have implicated the apolipoprotein E (APOE) gene in the pathophysiology of primary open angle glaucoma, but there have been conflicting findings.
To resolve this issue we studied 140 cases and 73 controls that were carefully phenotyped, and used a logistic regression model to simultaneously analyze the effect of apolipoprotein E genotype and functional polymorphisms in the apolipoprotein E gene promoter while controlling for potentially confounding variables.
We found no evidence of an association between the apolipoprotein E promoter region polymorphisms and primary open angle glaucoma.
Apolipoprotein E promoter polymorphisms are unlikely to have a major impact on the pathophysiology of primary open angle glaucoma.
原发性开角型青光眼（POAG）是病因不明的迟发性视力丧失的主要原因。最近的基因关联研究表明载脂蛋白E（APOE）基因与原发性开角型青光眼的病理生理学有关，但结果存在矛盾。
为解决这一问题，我们研究了140例病例和73例对照，这些病例和对照都经过了仔细的表型分析，并使用逻辑回归模型在控制潜在混杂变量的同时，分析载脂蛋白E基因型和载脂蛋白E基因启动子中的功能多态性的影响。
我们没有发现载脂蛋白E启动子区域多态性与原发性开角型青光眼之间存在关联的证据。
载脂蛋白E启动子多态性不太可能对原发性开角型青光眼的病理生理学产生重大影响。
