Ebrahimi Behnam, Tucker Susan L, Li Donghui, Abbruzzese James L, Kurzrock Razelle
Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.
Cancer. 2004 Dec 15;101(12):2727-36. doi: 10.1002/cncr.20672.
Cytokines have been implicated in diverse processes that are relevant to pancreatic carcinoma, including cachexia, asthenia, and tumor growth. The objective of this study was to examine the association between serum levels of proinflammatory and antiinflammatory or angiogenic cytokines and the outcomes of patients with pancreatic carcinoma.
Serum cytokine levels were measured by enzyme-linked immunosorbent assay from 51 patients with pancreatic carcinoma and from 48-62 healthy volunteers. Cytokine levels were compared with disease manifestations and overall survival.
Circulating levels of vascular endothelial growth factor, tumor necrosis factor alpha, interleukin-1alpha (IL-1alpha), and IL-1beta were not elevated significantly in patients with pancreatic carcinoma, but levels of IL-6, IL-8, IL-10, and IL-1 receptor antagonist (IL-1RA) were elevated significantly (P <0.05). Cytokine levels were dichotomized based on an analysis of null Martingale residuals. Patients who had IL-6 levels > 5.2 pg/mL or IL-10 levels >9.8 pg/mL had significantly worse survival compared with patients who had lower IL-6 or IL-10 levels (P <0.05). IL-8 levels were not associated with survival differences. Patients who had IL-1RA levels <159 pg/mL had significantly worse survival compared with patients who had higher IL-1RA levels (P <0.05). Higher IL-6, IL-10, and IL-8 levels were associated with poor performance status and/or weight loss. In multivariate analysis, only T4 tumors and high IL-6 levels were selected as independent prognostic factors for poor survival.
Circulating levels of several cytokines were high in patients with pancreatic carcinoma, and their association with weight loss and poor performance status suggested that they may be involved in these disease manifestations. Furthermore, serum cytokine levels, in particular IL-6, may be a useful prognostic marker.
细胞因子参与了与胰腺癌相关的多种过程，包括恶病质、乏力和肿瘤生长。本研究的目的是检测促炎、抗炎或血管生成细胞因子的血清水平与胰腺癌患者预后之间的关联。
采用酶联免疫吸附测定法测量了51例胰腺癌患者和48 - 62名健康志愿者的血清细胞因子水平。将细胞因子水平与疾病表现和总生存期进行比较。
胰腺癌患者血管内皮生长因子、肿瘤坏死因子α、白细胞介素-1α（IL-1α）和IL-1β的循环水平未显著升高，但IL-6、IL-8、IL-10和IL-1受体拮抗剂（IL-1RA）水平显著升高（P <0.05）。根据无效鞅残差分析将细胞因子水平进行二分法划分。IL-6水平>5.2 pg/mL或IL-10水平>9.8 pg/mL的患者与IL-6或IL-10水平较低的患者相比，生存期显著更差（P <0.05）。IL-8水平与生存差异无关。IL-1RA水平<159 pg/mL的患者与IL-1RA水平较高的患者相比，生存期显著更差（P <0.05）。较高的IL-6、IL-10和IL-8水平与较差的体能状态和/或体重减轻相关。在多变量分析中，只有T4期肿瘤和高IL-6水平被选为生存不良的独立预后因素。
胰腺癌患者多种细胞因子的循环水平较高，它们与体重减轻和较差的体能状态相关，提示它们可能参与了这些疾病表现。此外，血清细胞因子水平，尤其是IL-6，可能是一个有用的预后标志物。
