Martín-Casabona N, Bahrmand A R, Bennedsen J, Thomsen V Ostergaard, Curcio M, Fauville-Dufaux M, Feldman K, Havelkova M, Katila M L, Köksalan K, Pereira M F, Rodrigues F, Pfyffer G E, Portaels F, Urgell J Rosselló, Rüsch-Gerdes S, Tortoli E, Vincent V, Watt B
Servicio de Microbiologia, Hospital Universitario Vail d'Hebron, Barcelona, Spain.
Int J Tuberc Lung Dis. 2004 Oct;8(10):1186-93.
To collect data on non-tuberculous mycobacteria (NTM) isolated from clinical laboratories in different countries to establish: 1) whether the isolation of NTM was increasing, 2) which species were increasing, and 3) whether there was any pattern of geographical distribution.
In 1996, the Working Group of the Bacteriology and Immunology Section of the International Union Against Tuberculosis and Lung Disease contacted 50 laboratories in different countries for the necessary information.
The number of patients reported with NTM was 36099 from 14 countries. Mycobacterium avium complex, M. gordonae, M. xenopi, M. kansasii and M. fortuitum were the five species most frequently isolated. There was a significant upward trend for M. avium complex and M. xenopi. Pigmented mycobacteria predominated in Belgium, the Czech Republic and the Mediterranean coast of Spain. Non-chromogenic mycobacteria were found to be predominant in the area of the Atlantic coast of Brazil and in Turkey, the United Kingdom, Finland and Denmark.
There was an increase in the number of NTM isolated from clinical samples of patients. Isolation of the most frequent species is constantly changing in most of the geographical areas, and newer species are emerging due to better diagnostic techniques to detect and identify NTM.
收集不同国家临床实验室分离出的非结核分枝杆菌（NTM）数据，以确定：1）NTM的分离数量是否在增加；2）哪些菌种在增加；3）是否存在任何地理分布模式。
1996年，国际防痨和肺部疾病联盟细菌学和免疫学分会工作组联系了不同国家的50个实验室以获取必要信息。
来自14个国家的NTM报告患者数为36099例。鸟分枝杆菌复合群、戈登分枝杆菌、蟾分枝杆菌、堪萨斯分枝杆菌和偶然分枝杆菌是最常分离出的5种菌种。鸟分枝杆菌复合群和蟾分枝杆菌有显著上升趋势。色素沉着分枝杆菌在比利时、捷克共和国和西班牙地中海沿岸占主导地位。非产色分枝杆菌在巴西大西洋沿岸地区以及土耳其、英国、芬兰和丹麦占主导地位。
从患者临床样本中分离出的NTM数量有所增加。在大多数地理区域，最常见菌种的分离情况不断变化，并且由于检测和鉴定NTM的诊断技术更好，新的菌种正在出现。
